GYS1

Across TCGA cell cohorts, GYS1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GYS1-associated genes across cancer lineages are OR2L8, CCR8, and OXT. Each is linked with GYS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GYS1-to-partner and partner-to-GYS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by GYS1-low versus GYS1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYS1→partner) and Y-score (partner→GYS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2L8 →	+0.046	+4.807	<.001	.006	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.147	+3.378	<.001	.001	3	1
BLOOD_Leukemia	PRM2 →	+0.033	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2L8 by GYS1 expression — BLOOD_Myeloma

Explore this box plot interactively →