Across TCGA patient cohorts, GYPE mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GYPE-associated genes across cancer lineages are RNA5SP422, RNA5SP423, and RNA5SP411. Each is linked with GYPE in more than 1 cancer types. Because this analysis shows association rather than direction, both GYPE-to-partner and partner-to-GYPE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYPE→partner) and Y-score (partner→GYPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP422 →	+0.449	+8.055	<.001	.007	3	2
UCEC	RNA5SP423 →	+0.815	+2.354	<.001	.002	3	2
UCEC	RNA5SP411 →	+1.313	+2.031	<.001	.007	3	2
UCEC	RNA5SP417 →	+0.672	+2.614	<.001	.001	3	2
BRCA	RNA5SP414 →	+0.216	+8.471	<.001	.005	3	1
LIHC	RNA5SP137 →	+0.458	+6.008	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

Exploration

GYPE survival (RNA) · tumor vs normal (RNA) · all GYPE data types