GYPA

Across TCGA patient cohorts, GYPA mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GYPA-associated genes across cancer lineages are eEF2, PDCD4, and Caspase-7-cleavedD198. Each is linked with GYPA in more than 1 cancer types. Because this analysis shows association rather than direction, both GYPA-to-partner and partner-to-GYPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GYPA-low versus GYPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GYPA→partner) and Y-score (partner→GYPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.388	+2.584	.020	.011	3	2
UCEC	PDCD4 →	-0.644	-2.584	.003	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.588	+2.827	.033	.035	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.520	+2.584	.028	.011	3	1
UCEC	JNK2 →	+0.234	+3.009	.011	.019	3	1
UCEC	Ku80 →	+0.231	+1.887	.035	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by GYPA expression — UCEC

Explore this box plot interactively →