GYPA

Across TCGA pan-cancer cohorts, GYPA RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GYPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GYPA RNA is repressed in tumor relative to normal tissue. In most cancer types GYPA is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where GYPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GYPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−1.002	<.001	10	view →
KICH	All	II,III,IV	−0.787	<.001	7	view →
KIRC	All	All	−0.354	<.001	6	view →
LUSC	All	All	−0.021	<.001	5	view →
LUAD	Female	II,III,IV	−0.038	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GYPA–KIRP

Open the KIRP breakdown →