GULOP

Across TCGA pan-cancer cohorts, GULOP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GULOP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GULOP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GULOP is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

KIRC, LUAD, and UCEC are the cancer types where GULOP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GULOP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.351	<.001	8	view →
LUAD	Female	II,III,IV	−0.327	<.001	8	view →
UCEC	All	II,III,IV	−0.450	<.001	6	view →
THCA	All	II,III,IV	−0.226	<.001	5	view →
COAD	All	All	−0.210	.001	5	view →
LUSC	All	II,III,IV	−0.166	.009	4	view →
KICH	All	All	−0.189	.002	3	view →
HNSC	Male	All	−0.076	.030	3	view →
KIRP	Male	All	−0.300	.018	2	view →
BRCA	All	III,IV	−0.255	.025	2	view →
PRAD	All	All	+0.194	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GULOP–KIRC

Open the KIRC breakdown →