GUK1

Across TCGA pan-cancer cohorts, GUK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GUK1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GUK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where GUK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.447	0.897	.002	38	view →
CCRCC	OS	Quartile	All	0.701	1.000	.001	15	view →
PDAC	OS	Median	IV	0.491	0.836	.024	6	view →
HNSC	DFS	Quartile	IV	0.830	0.527	.020	6	view →
LUAD	OS	Median	III,IV	0.751	0.997	.036	3	view →
GBM	DFS	Median	All	0.234	0.400	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GUK1–LSCC (DFS)

Open the LSCC breakdown →