GUCY2D

Across TCGA patient cohorts, GUCY2D mutation is significantly associated with the RNA expression of many other genes, with 3,775 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY2D-associated genes across cancer lineages are RNU6-741P, ENO1, and EXOSC9. Each is linked with GUCY2D in more than 2 cancer types. Because this analysis shows association rather than direction, both GUCY2D-to-partner and partner-to-GUCY2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-741P grouped by GUCY2D-low versus GUCY2D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2D→partner) and Y-score (partner→GUCY2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-741P →	+0.071	+2.797	<.001	.008	3	3
UCEC	ENO1 →	+0.471	+2.263	.003	<.001	3	3
UCEC	EXOSC9 →	+0.419	+2.284	.001	<.001	3	3
BLCA	MIR5680 →	+0.300	+4.433	<.001	.007	3	3
UCEC	ACOT7 →	+0.534	+2.157	.005	.009	3	3
CESC	NDUFA5P5 →	+0.100	+7.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,775 associations by consensus.

RNU6-741P by GUCY2D expression — SKCM

Explore this box plot interactively →