GUCY2D

Across TCGA patient cohorts, GUCY2D mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY2D-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and PDCD4. Each is linked with GUCY2D in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCY2D-to-partner and partner-to-GUCY2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GUCY2D-low versus GUCY2D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2D→partner) and Y-score (partner→GUCY2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.281	+2.178	.006	.035	3	4
UCEC	A-Raf_pS299 →	-0.124	-2.700	.004	.006	3	2
UCEC	PDCD4 →	-0.543	-1.896	.001	.015	3	2
UCEC	Rab25 →	-0.318	-2.459	.009	.019	3	2
UCEC	TFRC →	+0.386	+1.874	.047	.049	3	2
COAD	Caspase-7-cleavedD198 →	+1.196	+2.824	.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

4E-BP1 by GUCY2D expression — COAD

Explore this box plot interactively →