GUCY2C

Across TCGA pan-cancer cohorts, GUCY2C mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of GUCY2C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GUCY2C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GUCY2C is over-expressed in tumor.

COAD and PDAC are the cancer types where GUCY2C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCY2C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.279	<.001	8	view →
PDAC	All	All	+0.851	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

GUCY2C–COAD

Open the COAD breakdown →