GUCY1B1

Across TCGA patient cohorts, GUCY1B1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,308 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GUCY1B1-associated genes across cancer lineages are EMCN, GUCY1A1, and PODN. Each is linked with GUCY1B1 in more than 9 cancer types. Because this analysis shows association rather than direction, both GUCY1B1-to-partner and partner-to-GUCY1B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCY1B1 versus EMCN in CCRCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1B1→partner) and Y-score (partner→GUCY1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EMCN →	+1.187	+0.315	<.001	<.001	3	10
BRCA	GUCY1A1 →	+1.381	+0.443	<.001	<.001	3	10
OV	PODN →	+1.337	+0.428	<.001	<.001	3	10
CCRCC	FHL5 →	+1.086	+0.399	<.001	<.001	3	9
UCEC	CNRIP1 →	+0.939	+0.650	<.001	<.001	3	9
CCRCC	TEK →	+1.118	+0.384	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,308 associations by consensus.

GUCY1B1 vs EMCN — CCRCC

Explore this scatter interactively →