GUCY1B1

Across TCGA patient cohorts, GUCY1B1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1B1-associated genes across cancer lineages are MIG-6, A-Raf_pS299, and GSK-3_pS9. Each is linked with GUCY1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY1B1-to-partner and partner-to-GUCY1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by GUCY1B1-low versus GUCY1B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1B1→partner) and Y-score (partner→GUCY1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.098	+3.381	.034	.004	3	2
UCEC	A-Raf_pS299 →	-0.131	-3.169	.006	.018	3	1
UCEC	GSK-3_pS9 →	+0.399	+2.000	.014	.030	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.516	+3.584	.002	.002	3	1
UCEC	Heregulin →	-0.135	-2.000	.006	.030	3	1
UCEC	Ku80 →	+0.271	+3.100	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MIG-6 by GUCY1B1 expression — COAD

Explore this box plot interactively →