GUCY1A2

Across TCGA cell cohorts, GUCY1A2 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GUCY1A2-associated genes across cancer lineages are OR52E4, PRAMEF10, and FAM47C. Each is linked with GUCY1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY1A2-to-partner and partner-to-GUCY1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E4 grouped by GUCY1A2-low versus GUCY1A2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A2→partner) and Y-score (partner→GUCY1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR52E4 →	+0.089	+4.736	<.001	.009	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	FAM47C →	+0.069	+4.736	<.001	.009	3	2
LUNG_SCLC	PRAMEF15 →	+0.478	+4.817	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	OR2J1 →	+0.109	+4.736	<.001	.009	3	2
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

OR52E4 by GUCY1A2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →