GUCY1A1

Across TCGA cell cohorts, GUCY1A1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GUCY1A1-associated genes across cancer lineages are SPATA19, SLC22A7, and LY6G6D. Each is linked with GUCY1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY1A1-to-partner and partner-to-GUCY1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by GUCY1A1-low versus GUCY1A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1A1→partner) and Y-score (partner→GUCY1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA19 →	+0.022	+5.569	<.001	.001	3	2
SKIN	SLC22A7 →	+0.015	+3.700	<.001	.009	3	2
SKIN	LY6G6D →	+0.106	+3.103	<.001	.004	3	2
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SERPINB11 →	+0.028	+4.874	<.001	.002	3	1
BLOOD_Leukemia	SLC13A2 →	+0.015	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SPATA19 by GUCY1A1 expression — BLOOD_Leukemia

Explore this box plot interactively →