GUCA2B

Across TCGA pan-cancer cohorts, GUCA2B mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GUCA2B data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GUCA2B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GUCA2B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC and PDAC are the cancer types where GUCA2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.947	0.630	.012	19	view →
PDAC	OS	Quartile	II,III,IV	0.398	0.778	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GUCA2B–HNSC (OS)

Open the HNSC breakdown →