GUCA2B

Across TCGA patient cohorts, GUCA2B protein abundance is significantly associated with the RNA expression of many other genes, with 3,271 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GUCA2B-associated genes across cancer lineages are CENPA, SKA1, and IFFO1. Each is linked with GUCA2B in more than 3 cancer types. Because this analysis shows association rather than direction, both GUCA2B-to-partner and partner-to-GUCA2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCA2B versus CENPA in OV, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2B→partner) and Y-score (partner→GUCA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CENPA →	-1.443	-1.061	.009	.002	3	4
BRCA	SKA1 →	-1.182	-0.683	.003	.003	3	4
BRCA	IFFO1 →	+1.070	+1.061	.001	<.001	3	2
BRCA	BTK →	+1.326	+1.031	<.001	<.001	3	2
HNSC	KIF18A →	-0.852	-0.752	.007	<.001	2	3
UCEC	NTRK3 →	+0.619	+0.398	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,271 associations by consensus.

GUCA2B vs CENPA — OV

Explore this scatter interactively →