GUCA2B

Across TCGA patient cohorts, GUCA2B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA2B-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Caspase-7-cleavedD198, and Notch1. Each is linked with GUCA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA2B-to-partner and partner-to-GUCA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by GUCA2B-low versus GUCA2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2B→partner) and Y-score (partner→GUCA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.505	+3.000	.040	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.981	+2.827	.004	.035	3	1
UCEC	Notch1 →	+0.244	+3.000	.002	.037	1	2
UCEC	EGFR →	-0.242	-3.000	.008	.037	1	1
UCEC	GATA3 →	-0.309	-2.986	.004	.037	1	1
UCEC	Tuberin →	+0.386	+3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK-3a-b_pS21_S9 by GUCA2B expression — UCEC

Explore this box plot interactively →