GUCA2B

Across TCGA cell cohorts, GUCA2B RNA expression is significantly associated with the go_rna of many other GO terms, with 240 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible GUCA2B-associated GO terms across cancer lineages are Trans-synaptic signaling by BDNF, modulating synaptic transmission, Trans-synaptic signaling by BDNF, and Response to rapamycin. Each is linked with GUCA2B in more than 4 cancer types. Because this analysis shows association rather than direction, both GUCA2B-to-partner and partner-to-GUCA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trans-synaptic signaling by BDNF, modulating synaptic transmission grouped by GUCA2B-low versus GUCA2B-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2B→partner) and Y-score (partner→GUCA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Trans-synaptic signaling by BDNF, modulating synaptic transmission →	-1.243	-0.378	<.001	.006	3	4
LIVER	Trans-synaptic signaling by BDNF →	-1.243	-0.378	<.001	.006	3	4
STOMACH	Response to rapamycin →	-0.114	-0.579	.004	.009	2	5
LARGE_INTESTINE	Serotonin biosynthetic process →	+1.134	+0.110	<.001	.002	2	4
LARGE_INTESTINE	Indole-containing compound biosynthetic process →	+1.204	+0.190	<.001	.003	2	4
STOMACH	Fructose catabolic process →	+0.191	+0.562	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

Trans-synaptic signaling by BDNF, modulating synaptic transmission by GUCA2B expression — LIVER

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