GUCA2B

Across TCGA cell cohorts, GUCA2B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GUCA2B-associated genes across cancer lineages are MAGEB4, ZAN, and STRA8. Each is linked with GUCA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA2B-to-partner and partner-to-GUCA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by GUCA2B-low versus GUCA2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2B→partner) and Y-score (partner→GUCA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1
LARGE_INTESTINE	ZAN →	+0.010	+4.467	.003	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	IFNA16 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPX6 →	+0.579	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MAGEB4 by GUCA2B expression — LARGE_INTESTINE

Explore this box plot interactively →