Across TCGA pan-cancer cohorts, GUCA2A mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated GUCA2A data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GUCA2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GUCA2A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC are the cancer types where GUCA2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.872	0.304	.031	10	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: GUCA2A tumor-vs-normal RNA expression · all GUCA2A data types