GUCA2A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GUCA2A mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA2A-associated genes across cancer lineages are p62 Lck ligand, Rad50, and Cyclin-B1. Each is linked with GUCA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA2A-to-partner and partner-to-GUCA2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2A→partner) and Y-score (partner→GUCA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp62 Lck ligand →+0.578+2.817.002.03621
UCECRad50 →-0.335-3.000.016.03721
UCECCyclin-B1 →+0.738+3.000.023.03721
UCECShc_pY317 →-0.213-3.000.015.03711
UCECBax →+0.356+3.000.010.03711
Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration