GUCA1C

Across TCGA patient cohorts, GUCA1C mutation is significantly associated with the RNA expression of many other genes, with 1,208 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA1C-associated genes across cancer lineages are PPP2R2D, EDRF1, and PRR13P3. Each is linked with GUCA1C in more than 2 cancer types. Because this analysis shows association rather than direction, both GUCA1C-to-partner and partner-to-GUCA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by GUCA1C-low versus GUCA1C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA1C→partner) and Y-score (partner→GUCA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP2R2D →	+0.358	+2.247	<.001	.005	3	3
SKCM	EDRF1 →	+0.487	+2.038	.001	.004	3	3
UCEC	PRR13P3 →	+0.382	+2.459	<.001	.002	3	2
UCEC	CHEK1 →	+0.796	+3.721	.001	<.001	3	2
UCEC	CCT5 →	+0.642	+3.711	.007	<.001	3	2
UCEC	BUB3 →	+0.652	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,208 associations by consensus.

PPP2R2D by GUCA1C expression — SKCM

Explore this box plot interactively →