GUCA1C

Across TCGA pan-cancer cohorts, GUCA1C RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated GUCA1C data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GUCA1C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUCA1C expression acts as an unfavorable survival marker, although some lineages such as ACC and STAD show a favorable association.

BLCA, READ, and LUAD are the cancer types where GUCA1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.302	0.458	.005	102	view →
READ	OS	Tertile	IV	0.111	0.893	<.001	75	view →
LUAD	OS	Tertile	III,IV	0.057	0.680	<.001	57	view →
KIRP	OS	Tertile	III,IV	0.225	0.627	.004	47	view →
UVM	OS	Tertile	All	0.638	0.971	<.001	45	view →
LUSC	DFS	Quartile	All	0.510	0.755	.004	34	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
ACC	DFS	Tertile	II,III,IV	0.839	0.462	.018	24	view →
BRCA	OS	Tertile	II,III,IV	0.880	0.959	.005	24	view →
PAAD	OS	Median	All	0.329	0.555	.012	18	view →
UCEC	OS	Tertile	All	0.894	0.932	.024	18	view →
LIHC	DFS	Tertile	II,III,IV	0.111	0.476	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GUCA1C–BLCA (DFS)

Open the BLCA breakdown →