GUCA1C

Across TCGA patient cohorts, GUCA1C mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA1C-associated genes across cancer lineages are ATM, EGFR_pY1068, and GATA6. Each is linked with GUCA1C in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA1C-to-partner and partner-to-GUCA1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GUCA1C-low versus GUCA1C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA1C→partner) and Y-score (partner→GUCA1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATM →	-0.337	-1.874	.042	.049	3	2
UCEC	EGFR_pY1068 →	-0.274	-3.000	.024	.036	3	1
UCEC	GATA6 →	-0.184	-3.452	.017	.005	2	2
UCEC	JNK2 →	+0.240	+2.834	.012	.034	3	1
UCEC	Shc_pY317 →	-0.267	-3.584	<.001	.002	3	1
UCEC	STAT3_pY705 →	-0.368	-2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by GUCA1C expression — SKCM

Explore this box plot interactively →