GUCA1B

Across TCGA patient cohorts, GUCA1B mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GUCA1B-associated genes across cancer lineages are LINC02222, MIR4727, and MIR6512. Each is linked with GUCA1B in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA1B-to-partner and partner-to-GUCA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02222 grouped by GUCA1B-low versus GUCA1B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA1B→partner) and Y-score (partner→GUCA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02222 →	+0.050	+4.502	<.001	.007	3	2
UCEC	MIR4727 →	+0.402	+3.329	<.001	.005	3	1
SKCM	MIR6512 →	+0.675	+3.794	.005	.003	3	1
BLCA	MIR5591 →	+0.420	+7.640	<.001	.009	3	1
SKCM	TMEM97P1 →	+0.207	+3.642	<.001	.005	3	1
SKCM	RNU7-19P →	+0.428	+4.098	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

LINC02222 by GUCA1B expression — LUAD

Explore this box plot interactively →