GUCA1B

Across TCGA pan-cancer cohorts, GUCA1B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GUCA1B data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GUCA1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated GUCA1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UCS, and KIRC are the cancer types where GUCA1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.570	0.290	.002	53	view →
UCS	OS	Tertile	III,IV	0.790	0.403	.011	48	view →
KIRC	DFS	Quartile	All	0.497	0.667	.005	47	view →
KIRP	DFS	Tertile	All	0.848	0.988	<.001	38	view →
SCLC	OS	Median	All	0.546	0.192	<.001	37	view →
ACC	DFS	Median	II,III,IV	0.385	0.756	.002	27	view →
GBM	DFS	Quartile	All	0.352	0.157	<.001	27	view →
COAD	DFS	Quartile	II,III,IV	0.261	0.628	<.001	25	view →
BLCA	DFS	Median	III,IV	0.641	0.498	.009	21	view →
LUSC	DFS	Quartile	III,IV	0.239	0.897	.006	19	view →
DLBC	DFS	Median	All	0.613	0.921	.006	19	view →
LGG	OS	Tertile	All	0.876	0.739	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GUCA1B–HNSC (OS)

Open the HNSC breakdown →