GTSF1

Across TCGA patient cohorts, GTSF1 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTSF1-associated genes across cancer lineages are TAF9, INO80B-WBP1, and MIR6780B. Each is linked with GTSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTSF1-to-partner and partner-to-GTSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by GTSF1-low versus GTSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTSF1→partner) and Y-score (partner→GTSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.740	+3.191	<.001	.009	3	1
UCEC	INO80B-WBP1 →	+0.114	+3.577	.001	.002	3	1
UCEC	MIR6780B →	+0.347	+2.889	<.001	.004	3	1
LUAD	DEFB103A →	+0.059	+7.930	<.001	.008	3	1
LUAD	MCUR1P2 →	+0.054	+7.930	<.001	.008	3	1
LUAD	RN7SKP46 →	+0.204	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

TAF9 by GTSF1 expression — UCEC

Explore this box plot interactively →