GTSE1

Across TCGA cell cohorts, GTSE1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTSE1-associated genes across cancer lineages are MAGEB4, C14orf178, and OR1Q1. Each is linked with GTSE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTSE1-to-partner and partner-to-GTSE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by GTSE1-low versus GTSE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTSE1→partner) and Y-score (partner→GTSE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	2
SKIN	C14orf178 →	+0.141	+3.691	.001	.009	2	2
LUNG_NSCLC_LUAD	OR1Q1 →	+0.079	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR5AU1 →	+0.027	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	IFNA14 →	+0.015	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	USP17L19 →	+0.004	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MAGEB4 by GTSE1 expression — LARGE_INTESTINE

Explore this box plot interactively →