GTPBP6

Across TCGA pan-cancer cohorts, GTPBP6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTPBP6 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GTPBP6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GTPBP6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where GTPBP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	25	view →
LSCC	DFS	Median	II,III,IV	1.000	0.844	.009	13	view →
LUAD	DFS	Median	All	0.907	0.682	.038	7	view →
GBM	DFS	Tertile	All	0.537	0.253	.004	4	view →
HNSC	DFS	Quartile	II,III,IV	0.519	0.869	.005	4	view →
UCEC	DFS	Median	II,III,IV	0.531	0.870	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTPBP6–CCRCC (DFS)

Open the CCRCC breakdown →