GTPBP6

Across TCGA pan-cancer cohorts, GTPBP6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GTPBP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GTPBP6 RNA is repressed in tumor relative to normal tissue. In most cancer types GTPBP6 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where GTPBP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTPBP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.708	<.001	10	view →
LIHC	Male	II,III,IV	+1.140	<.001	9	view →
THCA	All	IV	−0.587	<.001	9	view →
STAD	Male	II,III,IV	+0.672	<.001	7	view →
KIRP	Male	All	−0.869	<.001	6	view →
COAD	All	All	+0.528	<.001	6	view →
CHOL	All	All	+1.584	<.001	5	view →
BRCA	Female	II,III,IV	−0.213	.025	4	view →
PRAD	All	All	+0.281	<.001	2	view →
LUAD	All	All	−0.201	.018	2	view →
ESCA	All	All	+0.602	.016	1	view →
READ	Female	All	+0.443	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GTPBP6–KICH

Open the KICH breakdown →