GTPBP6

Across TCGA patient cohorts, GTPBP6 mutation is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP6-associated genes across cancer lineages are MIR8075, MIR4674, and AKAP5. Each is linked with GTPBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP6-to-partner and partner-to-GTPBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8075 grouped by GTPBP6-low versus GTPBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP6→partner) and Y-score (partner→GTPBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8075 →	+0.723	+2.011	.001	.003	3	2
BLCA	MIR4674 →	+0.338	+4.899	<.001	.005	3	2
UCEC	AKAP5 →	+0.450	+2.592	.002	.006	3	2
BRCA	RNU2-8P →	+0.192	+6.725	<.001	<.001	3	2
UCEC	TOP3A →	+0.611	+3.753	<.001	<.001	3	2
UCEC	TIMM22 →	+0.415	+3.691	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

MIR8075 by GTPBP6 expression — UCEC

Explore this box plot interactively →