GTPBP6

Across TCGA patient cohorts, GTPBP6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP6-associated genes across cancer lineages are ATM, C-Raf, and eEF2. Each is linked with GTPBP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTPBP6-to-partner and partner-to-GTPBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GTPBP6-low versus GTPBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP6→partner) and Y-score (partner→GTPBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.726	-2.700	<.001	.006	3	3
UCEC	C-Raf →	+0.184	+2.321	.004	.034	3	2
UCEC	eEF2 →	+0.431	+2.999	.007	.035	3	1
UCEC	EGFR_pY1068 →	-0.323	-2.000	.004	.032	3	1
UCEC	EGFR →	-0.218	-2.000	.002	.032	3	1
UCEC	A-Raf_pS299 →	-0.177	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by GTPBP6 expression — UCEC

Explore this box plot interactively →