GTPBP6

Across TCGA cell cohorts, GTPBP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,205 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GTPBP6-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, DNA replication proofreading, and Subtelomeric heterochromatin formation. Each is linked with GTPBP6 in more than 11 cancer types. Because this analysis shows association rather than direction, both GTPBP6-to-partner and partner-to-GTPBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by GTPBP6-low versus GTPBP6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP6→partner) and Y-score (partner→GTPBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.173	+1.079	<.001	<.001	3	12
BONE	DNA replication proofreading →	+0.236	+1.068	.001	<.001	3	12
BONE	Subtelomeric heterochromatin formation →	+0.108	+1.001	<.001	<.001	3	12
PANCREAS	Methylglyoxal metabolic process →	+0.087	+0.823	.001	<.001	3	12
LUNG_NSCLC_LUSC	Mitochondrial ADP transmembrane transport →	+0.112	+1.184	<.001	.005	2	12
SOFT_TISSUE	Metanephric proximal tubule development →	+0.247	+1.068	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,205 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by GTPBP6 expression — BONE

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