GTPBP6

Across TCGA cell cohorts, GTPBP6 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTPBP6-associated genes across cancer lineages are MSGN1, TAFA1, and TRARG1. Each is linked with GTPBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP6-to-partner and partner-to-GTPBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by GTPBP6-low versus GTPBP6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP6→partner) and Y-score (partner→GTPBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	LRRC3C →	+0.327	+3.658	<.001	.005	3	1
LARGE_INTESTINE	KRTAP5-6 →	+0.325	+3.473	<.001	.008	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.139	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSGN1 by GTPBP6 expression — LARGE_INTESTINE

Explore this box plot interactively →