GTPBP3

Across TCGA pan-cancer cohorts, GTPBP3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTPBP3 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GTPBP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GTPBP3 expression acts as an unfavorable survival marker.

HNSC, UCEC, and SKCM are the cancer types where GTPBP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.087	0.768	<.001	48	view →
UCEC	OS	Median	III,IV	0.082	0.593	.013	18	view →
SKCM	DFS	Median	All	0.063	0.757	<.001	9	view →
LUAD	OS	Median	II,III,IV	0.079	0.677	<.001	6	view →
LIHC	OS	Median	All	0.025	0.775	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTPBP3–HNSC (OS)

Open the HNSC breakdown →