GTPBP3

Across TCGA pan-cancer cohorts, GTPBP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GTPBP3 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GTPBP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GTPBP3 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where GTPBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.555	0.829	.009	13	view →
PDAC	DFS	Median	III,IV	0.365	0.828	.015	5	view →
LUAD	OS	Median	III,IV	0.453	0.761	.014	3	view →
GBM	OS	Tertile	All	0.650	0.413	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GTPBP3–HNSC (OS)

Open the HNSC breakdown →