GTPBP3

Across TCGA patient cohorts, GTPBP3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP3-associated genes across cancer lineages are c-Met_pY1235, ERK2, and EGFR. Each is linked with GTPBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTPBP3-to-partner and partner-to-GTPBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by GTPBP3-low versus GTPBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP3→partner) and Y-score (partner→GTPBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.075	+2.331	.024	.019	3	3
UCEC	ERK2 →	+0.228	+3.169	.008	.018	3	2
UCEC	EGFR →	-0.153	-2.000	.034	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.119	-2.321	.035	.033	3	1
UCEC	JNK2 →	+0.236	+2.000	.008	.032	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.435	-3.169	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

c-Met_pY1235 by GTPBP3 expression — UCEC

Explore this box plot interactively →