GTPBP3

Across TCGA cell cohorts, GTPBP3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTPBP3-associated genes across cancer lineages are KRTAP4-12, PAK5, and TCF21. Each is linked with GTPBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP3-to-partner and partner-to-GTPBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-12 grouped by GTPBP3-low versus GTPBP3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP3→partner) and Y-score (partner→GTPBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP4-12 →	+0.035	+4.781	<.001	.003	3	1
BLOOD_Leukemia	PAK5 →	+0.124	+4.234	<.001	.003	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.289	+3.705	<.001	.007	3	1
BLOOD_Leukemia	PSG8 →	+0.030	+3.959	<.001	.005	3	1
BLOOD_Leukemia	GH2 →	+0.017	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

KRTAP4-12 by GTPBP3 expression — BREAST

Explore this box plot interactively →