GTPBP2

Across TCGA cell cohorts, GTPBP2 mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTPBP2-associated genes across cancer lineages are PRAMEF1, DUSP21, and PADI6. Each is linked with GTPBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP2-to-partner and partner-to-GTPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF1 grouped by GTPBP2-low versus GTPBP2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP2→partner) and Y-score (partner→GTPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRAMEF1 →	+0.025	+4.432	<.001	.003	3	1
STOMACH	DUSP21 →	+0.017	+4.285	<.001	.007	3	1
STOMACH	PADI6 →	+0.011	+4.129	<.001	.007	3	1
LARGE_INTESTINE	SLC5A1 →	+1.485	+3.082	.004	.007	3	1
LARGE_INTESTINE	SYF2 →	+0.486	+3.212	.005	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

PRAMEF1 by GTPBP2 expression — STOMACH

Explore this box plot interactively →