GTPBP1

Across TCGA pan-cancer cohorts, GTPBP1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GTPBP1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher GTPBP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GTPBP1 expression acts as an unfavorable survival marker.

ESCA, BLCA, and LUSC are the cancer types where GTPBP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.074	0.703	<.001	48	view →
BLCA	OS	Median	All	0.097	0.688	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.181	0.742	.007	12	view →
SKCM	OS	Median	All	0.245	0.781	.008	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUAD	OS	Median	III,IV	0.228	0.677	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GTPBP1–ESCA (OS)

Open the ESCA breakdown →