GTPBP1

Across TCGA pan-cancer cohorts, GTPBP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GTPBP1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where GTPBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTPBP1 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

LIHC, HNSC, and CHOL are the cancer types where GTPBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTPBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+0.754	<.001	9	view →
HNSC	Male	All	+0.741	<.001	8	view →
CHOL	Male	All	+1.924	<.001	5	view →
LUAD	Male	All	−0.479	<.001	5	view →
ESCA	Female	All	+1.080	.003	4	view →
UCEC	All	All	−0.647	<.001	4	view →
KIRC	Male	II,III,IV	−0.321	.009	3	view →
BLCA	All	IV	−0.762	.007	1	view →
STAD	Male	II,III,IV	+0.625	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GTPBP1–LIHC

Open the LIHC breakdown →