GTPBP1

Across TCGA pan-cancer cohorts, GTPBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GTPBP1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GTPBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTPBP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where GTPBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.379	0.853	<.001	26	view →
HNSC	DFS	Tertile	III,IV	0.884	0.643	.015	12	view →
PDAC	OS	Tertile	II,III,IV	0.577	0.367	.026	6	view →
GBM	OS	Quartile	All	0.637	0.453	.028	3	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GTPBP1–LSCC (DFS)

Open the LSCC breakdown →