GTPBP1

Across TCGA patient cohorts, GTPBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTPBP1-associated genes across cancer lineages are MIR3908, RNU6-1124P, and PRG3. Each is linked with GTPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP1-to-partner and partner-to-GTPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by GTPBP1-low versus GTPBP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP1→partner) and Y-score (partner→GTPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3908 →	+0.286	+4.345	<.001	.002	3	2
BLCA	RNU6-1124P →	+0.398	+7.640	<.001	.009	3	2
READ	PRG3 →	+0.258	+5.925	.001	.002	3	1
READ	OR5B21 →	+0.076	+5.219	.001	.006	3	1
READ	RNU6-13P →	+0.546	+5.039	<.001	.008	3	1
READ	FOXO1B →	+0.166	+5.039	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

MIR3908 by GTPBP1 expression — CESC

Explore this box plot interactively →