GTPBP1

Across TCGA cell cohorts, GTPBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,608 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTPBP1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Negative regulation of transcription initiation by RNA polymerase II, and Regulation of protein localization to nucleus. Each is linked with GTPBP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both GTPBP1-to-partner and partner-to-GTPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by GTPBP1-low versus GTPBP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP1→partner) and Y-score (partner→GTPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome condensation →	+0.190	+1.479	<.001	<.001	3	17
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.130	+1.333	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to nucleus →	+0.087	+1.469	<.001	<.001	3	16
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.130	+1.333	<.001	<.001	3	16
SKIN	Positive regulation of T-helper 17 cell lineage commitment →	+0.226	+1.100	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Nuclear migration along microtubule →	+0.116	+0.664	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,608 associations by consensus.

Negative regulation of chromosome condensation by GTPBP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →