GTPBP1

Across TCGA cell cohorts, GTPBP1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTPBP1-associated genes across cancer lineages are KRTAP4-1, C8orf86, and OPN1MW. Each is linked with GTPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTPBP1-to-partner and partner-to-GTPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-1 grouped by GTPBP1-low versus GTPBP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTPBP1→partner) and Y-score (partner→GTPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP4-1 →	+0.162	+4.867	<.001	.009	3	2
OESOPHAGUS	C8orf86 →	+0.153	+4.392	.002	.003	3	1
OESOPHAGUS	OPN1MW →	+0.032	+4.392	.002	.003	3	1
BLOOD_Leukemia	APOA4 →	+0.039	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SMR3B →	+0.030	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TEX26 →	+0.032	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

KRTAP4-1 by GTPBP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →