GTF3C2-AS1

Across TCGA pan-cancer cohorts, GTF3C2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GTF3C2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GTF3C2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF3C2-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where GTF3C2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF3C2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.111	<.001	11	view →
COAD	Male	II,III,IV	+0.258	<.001	10	view →
KIRC	All	All	+0.069	<.001	8	view →
LUAD	All	All	+0.229	.001	6	view →
BLCA	All	III,IV	+0.228	.001	6	view →
LUSC	Male	II,III,IV	+0.329	<.001	5	view →
LIHC	Male	All	+0.060	<.001	5	view →
STAD	Male	II,III,IV	+0.284	.007	4	view →
READ	All	All	+0.315	.048	2	view →
CHOL	All	All	+0.311	.005	2	view →
UCEC	All	All	+0.152	.032	2	view →
KICH	All	All	−0.065	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GTF3C2-AS1–HNSC

Open the HNSC breakdown →