GTF3A

Across TCGA pan-cancer cohorts, GTF3A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GTF3A data layer compared with 25 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GTF3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GTF3A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where GTF3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.722	0.936	.001	66	view →
PDAC	DFS	Median	III,IV	0.923	0.297	.002	13	view →
GBM	DFS	Tertile	All	0.275	0.494	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GTF3A–CCRCC (OS)

Open the CCRCC breakdown →