GTF2IRD1

Across TCGA patient cohorts, GTF2IRD1 mutation is significantly associated with the RNA expression of many other genes, with 2,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IRD1-associated genes across cancer lineages are MRPL49, BUB3, and PKN3. Each is linked with GTF2IRD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GTF2IRD1-to-partner and partner-to-GTF2IRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49 grouped by GTF2IRD1-low versus GTF2IRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD1→partner) and Y-score (partner→GTF2IRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.373	+1.954	.003	<.001	3	3
SKCM	BUB3 →	+0.408	+1.944	.001	<.001	3	3
STAD	PKN3 →	+0.730	+3.338	.006	.005	3	3
UCEC	GLOD4 →	+0.394	+2.110	<.001	<.001	3	3
UCEC	MRM3 →	+0.299	+3.828	.004	<.001	3	3
UCEC	NCAPH2 →	+0.408	+1.857	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,725 associations by consensus.

MRPL49 by GTF2IRD1 expression — UCEC

Explore this box plot interactively →