GTF2IRD1

Across TCGA pan-cancer cohorts, GTF2IRD1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GTF2IRD1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GTF2IRD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF2IRD1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

COAD, LUAD, and LUSC are the cancer types where GTF2IRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2IRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.532	<.001	12	view →
LUAD	Male	II,III,IV	+1.143	<.001	11	view →
LUSC	Male	III,IV	+1.962	<.001	9	view →
LIHC	Female	II,III,IV	+1.461	<.001	9	view →
THCA	Female	All	+0.586	<.001	9	view →
KICH	Female	II,III,IV	−1.364	<.001	8	view →
BLCA	Male	All	+1.097	<.001	8	view →
KIRP	All	IV	+1.302	<.001	6	view →
UCEC	All	III,IV	+1.148	<.001	6	view →
BRCA	All	II,III,IV	+0.989	<.001	6	view →
READ	Female	All	+2.172	<.001	5	view →
STAD	All	II,III,IV	+1.098	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GTF2IRD1–COAD

Open the COAD breakdown →