GTF2IRD1

Across TCGA cell cohorts, GTF2IRD1 mutation is significantly associated with the RNA expression of many other genes, with 537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2IRD1-associated genes across cancer lineages are FRG1, METTL4, and IL27RA. Each is linked with GTF2IRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IRD1-to-partner and partner-to-GTF2IRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG1 grouped by GTF2IRD1-low versus GTF2IRD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IRD1→partner) and Y-score (partner→GTF2IRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FRG1 →	+0.406	+3.212	.007	.006	3	2
LARGE_INTESTINE	METTL4 →	+0.548	+2.502	.003	.005	3	2
LARGE_INTESTINE	IL27RA →	+1.006	+3.321	.001	.003	3	2
LARGE_INTESTINE	CDH24 →	+0.777	+2.502	.004	.005	3	2
LARGE_INTESTINE	CHAC2 →	+0.639	+3.628	.008	<.001	3	2
LARGE_INTESTINE	PRIMPOL →	+0.646	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 537 associations by consensus.

FRG1 by GTF2IRD1 expression — SKIN

Explore this box plot interactively →