GTF2IP4

Across TCGA patient cohorts, GTF2IP4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2IP4-associated genes across cancer lineages are OR4K4P, MIR1266, and MIR1205. Each is linked with GTF2IP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2IP4-to-partner and partner-to-GTF2IP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K4P grouped by GTF2IP4-low versus GTF2IP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2IP4→partner) and Y-score (partner→GTF2IP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR4K4P →	+0.089	+7.816	<.001	.008	3	1
UCEC	MIR1266 →	+0.446	+4.771	<.001	.006	3	1
UCEC	MIR1205 →	+0.922	+4.633	.002	.004	3	1
UCEC	HMGN2P34 →	+0.427	+4.398	<.001	.006	3	1
UCEC	RNU7-125P →	+0.868	+4.690	<.001	.003	3	1
UCEC	RNU6-1315P →	+0.596	+4.233	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR4K4P by GTF2IP4 expression — SKCM

Explore this box plot interactively →